Saturday, August 18, 2018

HPLC-12

Causes for Pressure Fluctuations

In HPLC, Pressure fluctuations mainly occur due to the following:
  • Leaks in Pump seal
  • Leaks in tubings
  • Inline bubble traps in pump, column and solvent tubings
Solutions:
Bubble traps can be minimized by Degassing
Pump seal can be replaced to avoid leaks

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