Wednesday, June 20, 2018

RPC-02

Stationary phase in RPC

The stationary phase of RPC is non polar/hydrophobic (refer previous post RPC-01).The hydrophobic nature is achieved by the alkyl chains (C18, C8 and C4), amide, phenyl or cyano groups bonded to the stationary support silica. Order of increase in Hydrophobicity is C4<C8<C18. This statement shows C18 is more hydrophobic than C8 and C4 because 18 (CH3) alkyl groups are bounded to the silica support.
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